Asunto(s)
Tejido Adiposo/fisiopatología , COVID-19/complicaciones , COVID-19/fisiopatología , Obesidad/complicaciones , Abdomen/patología , Tejido Adiposo/diagnóstico por imagen , Humanos , Pulmón/patología , Modelos Teóricos , Obesidad Abdominal , Tamaño de los Órganos , Factores de Riesgo , Tomografía Computarizada por Rayos X , Carga ViralRESUMEN
A high incidence of thrombotic events has been reported in patients with coronavirus disease (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. We report 3 clinical cases of patients in Italy with COVID-19 who developed abdominal viscera infarction, demonstrated by computed tomography.
Asunto(s)
Anticoagulantes/uso terapéutico , Betacoronavirus/patogenicidad , Infecciones por Coronavirus/complicaciones , Heparina de Bajo-Peso-Molecular/uso terapéutico , Infarto/complicaciones , Neumonía Viral/complicaciones , Trombosis/complicaciones , Abdomen/irrigación sanguínea , Abdomen/patología , Abdomen/virología , Anciano , Antivirales/uso terapéutico , Betacoronavirus/efectos de los fármacos , COVID-19 , Infecciones por Coronavirus/diagnóstico por imagen , Infecciones por Coronavirus/terapia , Infecciones por Coronavirus/virología , Combinación de Medicamentos , Humanos , Hidroxicloroquina/uso terapéutico , Infarto/diagnóstico por imagen , Infarto/terapia , Infarto/virología , Italia , Lopinavir/uso terapéutico , Masculino , Persona de Mediana Edad , Pandemias , Neumonía Viral/diagnóstico por imagen , Neumonía Viral/terapia , Neumonía Viral/virología , Ritonavir/uso terapéutico , SARS-CoV-2 , Trombosis/diagnóstico por imagen , Trombosis/terapia , Trombosis/virología , Tomografía Computarizada por Rayos X , Vísceras/irrigación sanguínea , Vísceras/efectos de los fármacos , Vísceras/patología , Vísceras/virologíaRESUMEN
Background Angiotensin-converting enzyme 2, a target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), demonstrates its highest surface expression in the lung, small bowel, and vasculature, suggesting abdominal viscera may be susceptible to injury. Purpose To report abdominal imaging findings in patients with coronavirus disease 2019. Materials and Methods In this retrospective cross-sectional study, patients consecutively admitted to a single quaternary care center from March 27 to April 10, 2020, who tested positive for SARS-CoV-2 were included. Abdominal imaging studies performed in these patients were reviewed, and salient findings were recorded. Medical records were reviewed for clinical data. Univariable analysis and logistic regression were performed. Results A total of 412 patients (average age, 57 years; range, 18 to >90 years; 241 men, 171 women) were evaluated. A total of 224 abdominal imaging studies were performed (radiography, n = 137; US, n = 44; CT, n = 42; MRI, n = 1) in 134 patients (33%). Abdominal imaging was associated with age (odds ratio [OR], 1.03 per year of increase; P = .001) and intensive care unit (ICU) admission (OR, 17.3; P < .001). Bowel-wall abnormalities were seen on 31% of CT images (13 of 42) and were associated with ICU admission (OR, 15.5; P = .01). Bowel findings included pneumatosis or portal venous gas, seen on 20% of CT images obtained in patients in the ICU (four of 20). Surgical correlation (n = 4) revealed unusual yellow discoloration of the bowel (n = 3) and bowel infarction (n = 2). Pathologic findings revealed ischemic enteritis with patchy necrosis and fibrin thrombi in arterioles (n = 2). Right upper quadrant US examinations were mostly performed because of liver laboratory findings (87%, 32 of 37), and 54% (20 of 37) revealed a dilated sludge-filled gallbladder, suggestive of bile stasis. Patients with a cholecystostomy tube placed (n = 4) had negative bacterial cultures. Conclusion Bowel abnormalities and gallbladder bile stasis were common findings on abdominal images of patients with coronavirus disease 2019. Patients who underwent laparotomy often had ischemia, possibly due to small-vessel thrombosis. © RSNA, 2020.